Asady A, et al. – This report reviewed the clinical manifestation of cholinergic urticaria (CholU), duration of disease, comorbidities or response to treatment in patients of different age groups. Findings demonstrated that there were two subtypes of CholU patients with different gender ratios, disease duration, and comorbidities. Collected evidence indicated that two distinct underlying pathogenetic pathways were relevant in these two subgroups of CholU patients.