Fasugba O, et al. - In this cross-sectional, stepped-wedge, open-label, randomized controlled trial, the incidence of catheter-associated asymptomatic bacteriuria and urinary tract infection (UTI) was examined following meatal cleaning before urinary catheter insertion using 0.1% chlorhexidine solution vs normal saline. From Australian public and private hospitals with an intensive care unit and more than 30,000 hospital admissions per year, researchers included 1,642 participants, 697 (42%) in the control phase and 945 (58%) in the intervention period. The intervention comprised using 0.1% chlorhexidine solution for meatal cleaning before urinary catheterization vs using 0.9% normal saline in the control phase. Outcomes revealed a lower incidence of catheter-associated asymptomatic bacteriuria and UTI in correlation to using chlorhexidine solution for meatal cleaning before catheter insertion. The intervention correlated with a 74% decrease in the incidence of catheter-associated asymptomatic bacteriuria, and a 94% reduction in the incidence of catheter-associated UTI Furthermore, they identified no adverse events.