Hou D, et al. - Whether childhood pulse pressure (PP) and change in PP status is correlated with adult subclinical vascular damage was determined by analyzing data from a population-based cohort of children aged 6-18 years started in 1987, with 1,254 participants who were followed up in 2010-2011 (aged 28-42 years). Using carotid intima-media thickness (IMT), carotid arteriosclerosis was assessed. Aortic stiffness was evaluated using brachial-ankle pulse wave velocity (PWV). They found an independent association of both childhood PP and mean arterial pressure (MAP) with adult carotid IMT and PWV, adjusted for sex, childhood age, follow-up duration, and other traditional cardiovascular risk factors. The important part large PP in childhood plays in the development of subclinical vascular damage in adulthood was highlighted, as was the importance of early prevention of large PP to attenuate the future risk of cardiovascular disease.