Estrada-Prat X, et al. – In this systematic review, researchers summarized the literature on childhood factors that impact the risk for mood episode recurrences in bipolar disorder (BD). Childhood variables associated with mood recurrences were retrospectively evaluated in 20 pediatric studies and 28 studies involving adults. The investigators noted a higher number of recurrences in correlation with early age of onset, low socioeconomic status, comorbid disorders, inter-episode subsyndromal mood symptoms, BD-I/II subtypes, presence of stressors, and family history of BD. The impact of BD may be reduced via interventions targeting modifiable factors, according to findings. For example, risk related to many clinical factors could be reduced via the treatment of comorbid disorders and subsyndromal mood symptoms, coupled with appropriate cognitive behavioral and family-focused therapies. Reduction in the number of episodes and significant improvement in the course of BD could be achieved when treatment is coupled with social services to address environmental factors.