Reddy A, Jenssen B, Chidambaram A, et al. - Researchers conducted this retrospective case series to characterize patients with e‐cigarette vaping‐associated lung injury (EVALI) that require pediatric intensive care unit (PICU) level care. The sample consisted of patients ≤ 21 years old with confirmed or probable EVALI (as defined by the Centers for Disease Control) that resulted in admission to the PICU of a large tertiary academic children's hospital between August 2019 and January 2020. Six eligible patients were present, with a median age of 17 years. All patients reported use of tetrahydrocannabinol as well as nicotine e-cigarette. This single‐center case series outlines the presentation, course, and treatment of EVALI in a pediatric intensive care unit setting. The findings indicate nuanced variations in the presentation and management of the critically ill adolescents and pose several concerns about the long term consequences for pulmonary health, morbidity and mortality. Importantly, such events highlight the critical care ramifications of the public health phenomenon and should spur further research and policy to address the negative health effects of vaping.