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Characterization of phenotypic and genotypic traits of Klebsiella pneumoniae from lung cancer patients with respiratory infection

Infection and Drug Resistance Feb 04, 2020

Ding L, Yang Z, Lu J, et al. - Researchers sought to describe the frequency of K. pneumoniae in lung cancer patients with respiratory infection in a cancer hospital in China. Further, they investigated the antibiotic resistance profile, virulence phenotype, and clonal relationships among these K. pneumoniae strains. From September 2017 to October 2018, they identified a total of 47 lung cancer patients with respiratory infection caused by bacteria for this retrospective analysis. Among these, 27 patients were recognized to be positive for K. pneumoniae and the positive rate was 57.45%. From these 27 patients, they isolated 37 nonduplicate K. pneumoniae strains. Of the 37 strains, 19 isolates (51.4%) were classified as multidrug-resistant with high-level resistance to, at least one agent in three or more antibiotic categories, including polymyxin B and tigecycline; 16 (43.2%) were hypermucoviscous isolates. Two dominant PFGE types were identified in extended-spectrum β-lactamases-producing K. pneumoniae strains. Furthermore, virulence assessment using a G. mellonella larvae infection model led to the identification of a high virulence level in K. pneumoniae isolated from these patients. In view of these findings, they emphasize enhancing surveillance of K. pneumoniae strains and taking control measures.
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