Toriyama T, et al. - In this study, researchers aim at examining the existence of a subgroup of episodic migraineurs with widespread pressure hyperalgesia during and between attacks. In addition, they explore that if such a subgroup exists, what is the prevalence and what is the difference between groups with interictal widespread hyperalgesia and acute allodynia regarding the demographic and clinical characteristics of migraine. In the episodic migraineurs, the common occurrence of interictal widespread pressure hyperalgesia is observed (42%). It is associated with younger age at onset, female gender, and higher frequency of headache, but not duration of migraine illness. Presence of interictal widespread pressure hyperalgesia is assumed to be an indicator of genetic susceptibility to migraine attacks. In migraineurs, it is expected that a tender point count (as an alternative to quantitative sensory testing) may have utility as a diagnostic indicator of interictal hyperalgesia to predict susceptibility to migraine attacks and to permit tailored treatment.