Santos AR, et al. - In this retrospective cross-sectional study, researchers intended to characterize the type of retinal edema in the initial stages of retinopathy in type 2 diabetes. They examined eyes with minimal, mild, and moderate diabetic retinopathy (DR) by using spectral domain optical coherence tomography (OCT) layer by layer analysis of the retina in association with OCT-Leakage. They imaged 142 eyes from 142 patients (aged 52–88 years, 28% women). Independent of the severity of the retinopathy, similar prevalence of subclinical- and central-involved macular edema was demonstrated by eyes from diabetic patients in the initial stages of DR with different Early Treatment Diabetic Retinopathy Study gradings. Except in the earliest stages of diabetic retinal disease where predomination of intracellular edema is seen, retinal edema was located mainly in the inner nuclear layer and seemed to be mostly extracellular.