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Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: A retrospective case-control study

Journal of the American Academy of Dermatology Jun 04, 2018

Lee CKM, et al. - Experts evaluated the nature of dermatitis after Programmed Death (PD)-1/ PD-Ligand (L)1 inhibitor exposure and oncologic outcomes associated with dermatitis. Results demonstrated the probability of lichenoid and spongiotic dermatitis associated with PD-1/PD-L1 inhibitors to be a sign of robust immune response and improved oncologic outcomes. Lichenoid dermatitis (50%) and spongiotic dermatitis (40%) were the most common histologic patterns. For cases, overall tumour response rate was 65.0% and 17.0% for controls, odds ratio: 7.3.
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