Wang T, et al. - Researchers planned this study to compare differences in baseline characteristics of elderly patients with T2DM initiating sitagliptin vs non-DPP-4 inhibitor (non-DPP-4i) oral antihyperglycemic agent (OAHA) in the MarketScan Medicare Supplemental Database. Patients ≥ 65 years with T2DM initiating sitagliptin were found to be older and had more comorbidities compared to those prescribed other classes of OAHA. In any comparative analyses including users of sitagliptin, an appropriate adjustment was required to minimize the impact of potential confounding and channeling bias.