Hoppe JE, et al. - Researchers performed this study on children with cystic fibrosis (CF) between 8 and 18 years of age prescribed two weeks of oral antibiotics for a pulmonary exacerbation (PEx). They explored the characteristics of PEx managed on an outpatient basis and the effectiveness of oral antibiotic therapy by conducting a prospective assessment of clinical and laboratory changes associated with oral antibiotic treatment for PEx. Findings demonstrated that as a result of treating PEx with oral antibiotics, measurable improvements in patient-reported outcomes, lung function, bacterial density and sputum inflammatory markers were achieved.