Bhatt M, Porterfield JZ, Ribes JA, et al. - Given that cryptococcosis is classically associated with the immunocompromised patients but there is a rising appreciation for its effect on the immunocompetent hosts, researchers conducted this retrospective study to analyze the trends, diagnosis, treatment of different hosts and the effect of immunodeficiency and chronic liver disease on relapse and in-house mortality. Patients with cryptococcosis are classified into three groups; HIV-infected, transplant and non-HIV non-transplant (NHNT). Of the 114 identified patients, 23 (20.2%) had HIV infection, 11 (9.6%) had transplant, and 80 (70.2%) were NHNT patients. Chronic liver disease affected 30.7% (35/114) of all patients studied and it was a risk factor for in-hospital mortality. HIV infection and transplant had no statistically significant impact on mortality. Relapse occurred at a rate of 30.4% (7/23) in the HIV-infected patients. Such findings highlight the impact of immunocompromise type and degree on cryptococcosis.