Siegrist M, Heitkamp M, Braun I, et al. - In children with overweight/obesity, the impacts of short-term weight reduction on mean BMI and BMI-SDS (Standard Deviation Score) persisted over one year. Omentin-1 levels improved independent of short-term or long-term weight loss.

• There is scarcity of data on impacts of short-term lifestyle intervention in obese children on long-term follow-up body weight, adipokines and cardiometabolic risk parameters.

• A subgroup of the LOGIC-trial (Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence in Children) was analyzed for changes after 4 weeks of lifestyle intervention (n = 156, 14.0 ± 1.8 yrs) and after one year follow-up (n = 50) in children with overweight/obesity.

• A significant decrease in BMI and BMI-SDS was conferred by short-term lifestyle intervention.

• This intervention also led to significant decreases in hsCRP, leptin, and chemerin levels, and a rise in adiponectin and omentin-1 levels.

• Post-1 year follow-up, there was a significant decrease in BMI and BMI-SDS in children from the LOGIC-trial.

• Children with clear weight loss success (BMI-SDS reduction ≥ 0.2) exhibited improvements in adiponectin and chemerin levels.

• Whereas, an increase in leptin levels was observed in children with no or only mild weight loss success.

• Following 1 year, omentin-1 levels rose independent of weight change.