Mulligan AA, et al. - Researchers examined how changes in waist circumference (WC) are associated with all-cause and cardiovascular disease (CVD) mortality. In addition, they assessed these changes in relation to concurrent changes in weight. From the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study recruiting 25,639 participants between 1993 and 1997 with follow up available up to 2016 for mortality, they analyzed 12,337 eligible participants. After multivariable adjustment, for men and women with a WC gain (WCG) >  5 cm, the HRs (95% CIs) for all-cause mortality were 1.51 and 1.25, respectively; for CVD mortality, the HRs were 1.84 and 1.15, respectively. In analyses of concurrent changes in WC and weight, men exhibited the greatest risk (HRs) (95% CIs) with weight loss and WCG: 1.80 (1.13–2.86) for all-cause and 2.22 (1.03–4.82) for CVD mortality. In women with weight loss and maintenance of WC (WCM), they observed the greatest risk for both all-cause (HR 1.50 (1.16–1.95)) and CVD mortality (HR 1.81 (1.15–2.85)). These findings suggest the value of interventions focusing on preventing an increase in central adiposity rather than lowering weight per se in later life for achieving greater health benefits.