Vrbanović E, et al. - In this investigation, researchers explored the connection between oxidative stress (OS) markers, stress perception, and salivary cortisol (SC) in chronic, female temporomandibular disorders (TMD) subjects. In order to assess the influence of treatment on oxidative status, changes in OS markers and SC during occlusal splint therapy was tracked. Among people depending on the source and intensity of pain, they assumed that the impacts of TMD therapy would differ. Sixteen female patients were hired, and the study was completed by 12. A significant decrease in afternoon total antioxidant capacity (TAC) was noted after 3 months. The data show that in female TMD patients, occlusal splint treatment helps to increase their ability to remove free radicals. The issue remains whether or not, as a result of avoiding unnecessary processes, TAC decreases in this process once the increase in antioxidants effectively compensates for OS. In future investigations evaluating salivary OS markers and their association with perceived stress and SC in patients with TMD, the intensity and source of pain should be considered important factors.