Abou-Arab O, Kamel S, Bar S, et al. - Endothelial permeability is regulated by angiopoietins (Angs). In view of the implication of Ang-1 and 2 (Ang-1 and Ang-2) in endothelial stability through an antagonism effect, researchers conducted a prospective, single-center study describing as well as comparing changes in Ang levels after transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). They measured Ang-1 and Ang-2 in 60 consecutive patients (SAVR group [n = 30] and TAVR group [n = 30]) using an enzyme-linked immunosorbent assay right before surgery (T0), at the end of surgery (T1), and at day one (T2). Per outcomes, there were greater alterations of Ang homeostasis among patients undergoing SAVR vs TAVR, confirming a role for the use of cardiopulmonary bypass. Ang changes observed in correlation with paravalvular leakage after TAVR were similar to those observed with SAVR.