Gudin JA, et al. - Authors performed this prospective, observational study to evaluate changes from baseline in overall mean severity and interference scores on the Brief Pain Inventory scale and the use of concurrent pain medications at 3- and 6-month follow-up assessments in chronic pain patients treated with topical analgesics. They identified topical analgesics as effective and safe for the treatment of chronic pain. To confirm these findings, randomized controlled trials seemed necessary.