Wang A, Tian X, Zuo Y, et al. - The present study was performed to explore the relationship between change in triglyceride-glucose (TyG) index and the risk of cardiovascular disease (CVD) in the general population. Researchers recruited a total of 62,443 Chinese individuals who were free of CVD. They computed the TyG index as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2], and change in TyG index was characterized as the difference between the TyG index in 2010 and that in 2006. The association between change in TyG index and the risk of CVD was analyzed by using multivariable-adjusted Cox proportional hazard models and restricted cubic spline analysis. The results showed that substantial changes in the TyG index independently predict the risk of CVD in the general population. In TyG, monitoring long-term changes may assist with the early identification of individuals at high risk of CVD.