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Cerebrospinal fluid features in COVID-19 patients with neurologic manifestations: Correlation with brain MRI findings in 58 patients

The Journal of Infectious Diseases Dec 21, 2020

Lersy F, Benotmane I, Helms J, et al. - In patients with COVID-19, researchers characterized neurological manifestations of 58 patients, regarding cerebrospinal fluid (CSF) analysis and neuroimaging findings, in this single-center study. The sample consisted of 58 COVID-19 patients, mostly men (66%) with a median age of 62 years, with neurologic manifestations and SARS-CoV-2 RT-PCR screening on CSF analysis. Encephalopathy was frequently seen (81%), then pyramidal dysfunction (16%), seizures (10%), and headaches (5%). In total, 40% of patients showed an elevated albumin quotient, indicating impaired blood‐brain barrier integrity. Brain MRI abnormalities, particularly leptomeningeal enhancement (38%) and increased inflammatory markers in CSF are common in patients with COVID-19-related neurological manifestations, while SARS-CoV 2 detection in CSF remained minimal.

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