Cerebrospinal fluid biomarkers for unipolar depression
JAMA Psychiatry Jun 08, 2022
Why this study matters
It is well-known that < 40% and 60% of depressed patients have remission of symptoms with the first and second medications prescribed, respectively, which may be explained by the multifactorial pathogenesis underlying depression and the complex neurocircuitry involved.
A meta-analysis of 97 published studies involving CSF biomarkers in patients > 18 years of age was undertaken using the PRISMA and MOOSE reporting guidelines.
Results and conclusion
Of 165 CSF biomarkers evaluated, the CSF levels of IL-6, total protein, and cortisol were increased, while the CSF levels of homovanillic acid, γ-aminobutyric acid, somatostatin, brain-derived neurotrophic factor, amyloid-β 40, and transthyretin were lower in patients with unipolar depression compared to healthy controls.
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