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Celiac disease can be predicted by high levels of tissue transglutaminase antibodies in children and adolescents with type 1 diabetes

Pediatric Diabetes Dec 16, 2020

Bybrant MC, Udén E, Frederiksen F, et al. - This investigation draws on data from the Swedish prospective Better Diabetes Diagnosis study to ascertain if tissue transglutaminase antibodies (anti‐tTG) that were ≥ 10 times the upper limit of normal (10× ULN) predicted celiac disease (CD) in type 1 diabetes (T1D). From 2005 to 2010, 2,035 children and adolescents diagnosed with T1D were involved. Biopsies were conducted on 119 children and graded utilizing the Marsh‐Oberhüber classification. All of the 60 children with anti‐tTG ≥10x ULN had a biopsy-tested CD. Since all children and adolescents screened with T1D with tissue transglutaminase antibodies above 10 times the positive value 10x ULN had CD, it is suggested that guidelines for diagnosing CD in screened children, where biopsies may be excluded, should also extend to children and adolescents with T1D as a noninvasive process.

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