Kundra P, et al. - Researchers conducted this study to determine the equipotent dose of isolated upper limb injection of ceftriaxone in the upper limb (IUL) surgeries under tourniquet that would attain a peak bone marrow concentration (C_max) similar to systemic (ST) 1-g injection. Study participants were divided into two groups: ST and IUL. They administered 1 g of ceftriaxone to those in the ST group (n=5) 20 minutes before tourniquet inflation; those in the IUL group received a calculated dose (n=5, in each dosage: 200, 100, 75, and 50 mg) diluted in 50 mL of normal saline distally after tourniquet inflation. Using high-performance liquid chromatography, they analyzed ceftriaxone concentration. According to findings, IUL injection with 75 mg of ceftriaxone can be equipotent and as effective as ST 1-g injection in upper limb orthopedic surgeries under tourniquet.