Simmons R, et al. - The causes of death among persons with diagnosis of hepatitis C virus (HCV) in England were reported through record linkage. Researchers linked persons ≥1 year with anti-HCV/HCV-PCR tests reported to PHE sentinel surveillance during 2002-2016 to death registrations from the Office for National Statistics during 2008-2016. Death of 8.6% of the 204,265 with evidence of HCV was reported during the study period. Compared to the general population, a higher proportion of persons with HCV died of external causes (accidental poisoning from drugs), liver disease (end-stage liver disease, liver cancer, hepatitis, alcohol- and non–alcohol-related) and HIV. Persons with evidence of HCV died at lower median age than the general population (53 years vs 81 years). A relative reduction in liver-related deaths in 2016 compared with 2015 may be related to the introduction of new HCV treatments.