Philip N, et al. - Researchers ascertained if casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) could influence microbial counts, acidogenicity, and the relative abundance of specific caries- and health-associated bacterial ­species in polymicrobial biofilms. Biofilms treated with CPP-ACP exhibited relatively modest, but significant, declines in microbial colony forming units and acidogenicity compared to biofilms treated with control. In addition, the CPP-ACP treated biofilms showed significantly lower bacterial loads of cariogenic Scardovia wiggsiae and Prevotella denticola, and higher bacterial loads of commensal Streptococcus sanguinis, S. mitis/oralis, and S. salivarius/thermophilus than the control-treated biofilms. The outcomes show that CPP-ACP has attributes that attenuate virulence that can influence a beneficial microbial ecological change in the biofilm.