Nyberg J, Gustavsson S, Linde M, et al. - Via a national, prospective, population-based cohort study on 8-year-old Swedish men (n = 1,819,828) who underwent mandatory military conscription examinations during the years from 196 to 2005, researchers explored the longitudinal association between cardiovascular fitness in young adult men and future risk of migraine and determined consequent differential impacts among categories of BMI and blood pressure. A total of 22,533 men during follow-up, filled a prescription for migraine-specific medication. Following confounding adjustment, in comparison with high cardiovascular fitness, low and medium fitness raised the risk of migraine-specific medication. To evaluate potential impact measure modification, stratified analyses of this relationship by levels of BMI and blood pressure revealed that lower fitness levels rose risk of migraine in all groups except in underweight men or men with high diastolic blood pressure. Thus, a greater long-term risk of developing a pharmacological prescription-requiring migraine was noted in young men with lower cardiovascular fitness. This study provides information about risk factors for migraine in men, an understudied population in migraine analysis.