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Cardiovascular disease risks in younger vs older adult B‐cell non‐Hodgkin lymphoma survivors

Cancer Medicine May 28, 2021

Ocier K, Abdelaziz S, Kim S, et al. - Researchers estimated cardiovascular disease (CVD) risk among younger vs older B-cell non-Hodgkin's lymphoma (B-NHL) survivors relative to their respective general population cohorts, in this population-based study. They used the Utah Cancer Registry to identify B-NHL survivors diagnosed from 1997 to 2015; these were matched with up to five cancer-free persons on birth year, gender, and birth state, utilizing the statewide Utah Population Database. To estimate hazard ratios for B-NHL survivors diagnosed at < 65 years and ≥ 65 years old, experts employed Cox Proportional Hazards models. Higher relative risks of chronic rheumatic disease of the heart valves; peri-, endo-, and myocarditis; diseases of the arteries; and hypotension, were detected in younger B-NHL survivors vs older cancer survivors. Increased relative risks of heart disease overall and congestive heart failure were noted among B-NHL survivors of both age groups. Overall, higher risks of specific CVDs were present in younger B-NHL survivors than older B-NHL survivors, relative to their respective general population cohorts.

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