Cardiac valve calcification is associated with mortality in hemodialysis patients: A retrospective cohort study
BMC Nephrology Jan 28, 2022
In maintenance hemodialysis (MHD) patients, elevated risk of all-cause and cardiovascular mortality was observed in relation to presence of cardiac valve calcification (CVC), including mitral valve calcification (MVC) and aortic valve calcification (AVC). Regular follow-up with echocardiography may afford a valuable tool for risk stratification in MHD cases.
In this retrospective cohort study of 434 hemodialysis patients who had echocardiography for qualitative assessment of valve calcification, researchers investigated the impact of CVC on all-cause and cardiovascular mortality.
All-cause and cardiovascular mortality rates were significantly higher in patients with CVC, compared with patients without CVC.
Multivariate regression analyses revealed MVC (HR: 1.517) and AVC (HR: 1.433) as significant factors linked with all-cause mortality.
MVC (HR: 2.340) and AVC (HR: 2.410) were also identified as significant factors linked with cardiovascular mortality.
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