Lassen MCH, Qasim AN, Biering-Sørensen T, et al. - Among asymptomatic autosomal dominant polycystic kidney disease (ADPKD) patients not on dialysis (n = 110), researchers assessed global longitudinal strain (GLS) distribution as evaluated by two-dimensional speckle-tracking in this prospective study. They also investigated clinical variables related to higher (less negative) strain measurements in these patients, given that transmitral early filling velocity to early diastolic strain rate (E/SRe) represents a new measure of left ventricular filling pressure, which is frequently affected early in cardiac disease. Among ADPKD patients, higher GLS and E/SRe were commonly detected, even in those with preserved estimated glomerular filtration rate and normal left ventricular ejection fraction. Following multivariate logistic regression with backward model selection, male gender and β-blocker use continued to be significant as factors related to higher GLS, and β-blocker use remained significant as a factor related to higher E/SRe. Since GLS and E/SRe are early markers of cardiac dysfunction, these may be helpful in cardiovascular risk stratification in patients with ADPKD.