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Cancer risks associated with BRCA1 and BRCA2 pathogenic variants

Journal of Clinical Oncology Jan 28, 2022

Researchers used data from 3,184 BRCA1 and 2,157 BRCA2 families to report precise information on age-specific risk estimates of cancers, other than female breast and ovarian cancers, associated with pathogenic variants (PVs) in BRCA1 and BRCA2.

  • BRCA1 and BRCA2 PVs are noted to be linked with elevated risks of male breast, pancreatic, stomach, and prostate (only BRCA2 PVs) cancers in addition to female breast and ovarian cancers; but there appeared no correlation of PVs with the risks of other previously suggested cancers.

  • Relative to males, females are at higher risk of stomach cancer.

  • In men and women with BRCA1/2 PVs, cancer risk management may be refined using the estimates of age-specific risks.

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