Gaur S, et al. - In this retrospective study, researchers intended to evaluate relationship of apparent diffusion coefficient (ADC) and normalized ADC (ratio of tumor to nontumor tissue) with the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and updated International Society of Urological Pathology (ISUP) categories as well as to determine how to optimally use ADC metrics for objective assistance in categorizing lesions within PI-RADSv2 guidelines. For this study, 100 patients underwent 3-T multiparametric MRI of the prostate with an endorectal coil. Data displayed that ADC and normalized ADC inversely correlate with PI-RADSv2 and ISUP categories and can serve as quantitative metrics to assist with assigning PI-RADSv2 DWI category 4 or 5.