Grupp K, Grotelüschen R, Uzunoglu FG, et al. - Researchers investigated the predictive significance of C-reactive protein (CRP) and other circulating markers for the localization of intra-abdominal hollow organ perforation. Four hundred twenty-three patients with GI tract perforations were assessed for serum marker measures and were divided according to the intraoperative diagnosis into colorectal and upper GI tract perforation groups. Patients with colorectal perforations vs upper GI tract perforations exhibited higher levels of CRP; this indicates association of higher levels of CRP with perforations in the colorectal tract. Patients with intra-abdominal hollow organ perforations had worse clinical outcomes in correlation to exhibiting increased CRP levels. This suggests a possible utility of CRP as a marker for preoperative risk stratification and for prediction of the localization of the perforation site.