Huang T, Goodman M, Li X, et al. - Researchers investigated whether there exists a prospective relationship of C-reactive protein (CRP) with risk of developing obstructive sleep apnea (OSA). A total of 1,882 females from the Nurses’ Health Study (NHS; 2002-2012), 3,854 females from NHSII (1995-2013), 3,075 males from the Health Professionals Follow-up Study (HPFS; 1996-2012) and 1,919 females and males from the Multi-Ethnic Study of Atherosclerosis (MESA; 2000-2012) were observed. The participants had no diagnosis of OSA at baseline and CRP levels were available for them. Findings showed that a prospective association of higher CRP with elevated OSA risk was present, especially in younger people, underweight/normal-weight people or premenopausal women. The differential links by OSA phenotype/endotype indicated likely mechanisms by which inflammation acts to modulate OSA risk. Future investigations with repeated CRP measurements are warranted to corroborate these prospective links, given the dependence on a single CRP level measured a decade prior to OSA evaluation.