Shields BM, et al. - Researchers explored the link between log-transformed C-peptide levels and the duration of diabetes up to 40 years after diagnosis. Using nonlinear regression approaches, the pattern of connection between urinary C-peptide/creatinine ratio (UCPCR) and duration of diabetes in cross-sectional data from 1,549 people with type 1 diabetes was evaluated. The results obtained from the study supported two clear phases of C-peptide decline: an initial exponential fall over a 7-year period, followed by a prolonged stabilization where C-peptide levels no longer decline. Between these two phases, understanding the pathophysiological and immunological differences will give crucial insights into understanding β-cell survival.