Ranzani A, et al. - Researchers examined HIV-infected patients aged 50 years or older at increased risk of comorbidities and multidrug treatments in order to assess the potential drug–drug interactions (PDDIs) of antiretroviral (ARV) and other medications. Patients aged 50 years or older receiving ARV and non-ARV medications were analyzed in this cross-sectional study. Findings suggested that older patients with HIV are highly exposed to PDDIs between ARVs and comedications. Thereby suggesting the significance of the knowledge of their complete medication regimens and the screening for PDDIs and potentially inappropriate medications for preventing drug-related adverse outcomes in this population.