Zeng B, Yu K, Gao L, et al. - A systematic review and meta-analysis were conducted to compare the screening performance of synthesized mammography (SM) plus digital breast tomosynthesis (DBT) with digital mammography (DM) plus DBT or DM alone. Researchers carried out searches of Medline, Embase, Web of Science, and the Cochrane Library databases between January 2010 and January 2021. They enrolled eligible population-based studies on breast cancer screening comparing SM/DBT with DM/DBT or DM in asymptomatic women. This research enrolled 13 studies including a total of 1,370,670 participants. Using SM/DBT, screening has similar breast cancer detection but reduces recall and biopsy when compared with DM/DBT. SM/DBT improves CDR when compared with DM, but they have little difference in ICR. The findings illustrated that SM/DBT could replace DM/DBT in breast cancer screening to reduce radiation dose.