Xu M, Guo Y, Xue K, et al. - This study was undertaken to investigate if the brain iron concentration in schizophrenia exists abnormally of research significance. Researchers used quantitative susceptibility mapping (QSM) in this study to evaluate brain iron changes in the grey matter nuclei of patients with first-episode schizophrenia. The study enrolled 30 patients with first-episode schizophrenia and 30 age and gender-matched healthy controls. The results indicate reduced iron concentration in grey matter nuclei of patients with first-episode schizophrenia. The findings suggest that QSM provides superior sensitivity over R2* in the assessment of schizophrenia-related brain iron changes. The outcomes illustrated that QSM may be a potential biomarker for further understanding the pathophysiological mechanism of first-episode schizophrenia.