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Botulinum toxin treatment of spasticity targeted to muscle endplates: An international, randomised, evaluator-blinded study comparing two different botulinum toxin injection strategies for the treatment of upper limb spasticity

BMJ Open May 10, 2019

Rekand T, et al. - Researchers ascertained if botulinum neurotoxin (BoNT) injections that target the neuromuscular junction (NMJ) were non-inferior to current injection practices in terms of effectiveness. In this open-label prospective evaluator-blinded study, findings revealed that the proportion of responders at elbow flexors was 72.7% in the current practice group and 56.8% in the NMJ-targeted group in the intention-to-treat population. Comparable outcomes were noted in the per protocol population. Non-inferiority of NMJ-targeted injections could not be determined due to the limited number of participants, though there was no statistical difference between groups.

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