Zar-Kessler C, et al. - Researchers here investigated botulinum Toxin (BT) for childhood constipation, including response duration, symptom association and effectiveness in relation to sphincter dynamics. BT was observed to be efficacious for children with chronic constipation. The response was less frequent among patients with fecal incontinence. A prolonged beneficial response was evident in more than half of the patients. Patients with normal and abnormal sphincter dynamics showed similar responses and without differences in side effects. Therefore, in patients with intractable constipation unresponsive to medication, injection could be considered, regardless of anal sphincter dynamics.