Ellen M, et al. - Authors examined if body mass index (BMI) or vitamin D status was linked to MRI patterns of neurodegeneration either in relapsing-remitting multiple sclerosis (RRMS) or clinically isolated syndrome (CIS) cases with a longitudinal multiple sclerosis (MS) cohort study named, Expression, Proteomics, Imaging, Clinical (EPIC), at the University of California, San Francisco among 469 patients. After fixing for age, sex, ethnicity, smoking status, and use of MS treatments, they observed annual 25-hydroxyvitamin D levels and BMI in relation to subsequent brain volumes ie, normalized gray matter [nGMV], brain parenchymal [nBPV], and white matter volumes, as determined by Structural Image Evaluation using Normalization of Atrophy-X. They found a higher BMI be correlated with greater declines in nGMV and nBPV as nGMV loss forecasted longer-term disability.