East P, Delker E, Blanco E, et al. - According to the presence or absence of adult cardiometabolic (CM) risks, experts aspired to explore if the level, rate, and acceleration of BMI growth vary. BMI was measured in 1,000 Chileans at nine time points from birth to 23 years, and metabolic syndrome and its components were evaluated at young adulthood. People with CM risks had a particular constellation of early-life growth (faster growth after infancy, lower BMI decline approaching age 5, absence of a definitive BMI nadir in early childhood, higher 5-year BMI) and distinct young adult growth (larger BMI increases from childhood to young adulthood and lower levels of predicted deceleration of growth approaching young adulthood). Larger and faster rises in BMI and a failure of BMI growth to decline or decelerate at specific periods of development distinguished people who would and would not have adult CM risks.