Fonseca VR, et al. - Herein, researchers ascertained if the balance of blood T follicular helper (Tfh) and Foxp3+ T follicular regulatory (Tfr) cells could inform on ectopic lymphoid neogenesis and disease activity in primary Sjogren's syndrome (SS). Data demonstrated that blood Tfr/Tfh ratio and PD-1+ICOS+ Tfh cells presented as potential novel biomarkers for varied features of primary SS. Activated Tfh cells pointed towards disease activity while blood Tfr/Tfh ratio exhibited a link with ectopic lymphoid neogenesis.