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Blood pressure thresholds in pregnancy for identifying maternal and infant risk: A secondary analysis of Community-Level Interventions for Pre-eclampsia (CLIP) trial data

The Lancet Global Health Jul 25, 2021

Bone JN, Magee LA, Singer J, et al. - Researchers sought to explore the connections between blood pressure thresholds and adverse outcomes and the diagnostic test properties of these blood pressure cutoffs in low-resource settings. The data from 22 intervention clusters in the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials in India (n = 6), Mozambique (n = 6), and Pakistan (n = 10) were analyzed secondary. Between November 1, 2014, and February 28, 2017, 103,679 blood pressure measurements were collected from 21,069 women (6,067 in India, 4,163 in Mozambique, and 10,839 in Pakistan) across the three CLIP trials. Elevated blood pressure and stage 1 hypertension were not associated with maternal, fetal, or neonatal mortality or morbidity adverse composite outcomes in low-resource settings. Only the severe stage 2 hypertension threshold met diagnostic test performance standards. Current hypertension diagnostic thresholds in pregnancy should be maintained.

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