Levine DA, et al. -In this prospective national study, researchers assessed the impacts of baseline systolic and diastolic blood pressure (SBP and DBP), as well as pulse pressure (PP) and mean arterial pressure, on changes in cognition among 22,164 blacks and whites ≥45 years without baseline cognitive impairment or stroke from the REGARDS cohort study (Reasons for Geographic and Racial Differences in Stroke), enrolled 2003 to 2007 and followed through September 2015. Whether age, race, and sex modified the effects, was also investigated. In association with higher SBP and lower DBP, significantly faster declines in global cognition; higher PP was linked with increasing age. Faster declines in global cognition related to SBP and mean arterial pressure were exhibited by blacks vs whites. Faster declines in new learning were observed in men vs women in relation to SBP. After controlling for the impact of age on cognitive trajectories, findings revealed no association of BP with decline of verbal memory and executive function.