Rhone ET, et al. – The purpose of this study was to examine the association between birthweight and uric acid in American adolescents. Results displayed that lower birthweight was associated with higher uric acid in US adolescents. These findings probably supported the hypothesis that reduced nephron number was associated with elevated uric acid.

• This study consisted of 5390 US adolescents aged 12–15 in the National Health and Nutrition Examination Survey from 1999 to 2012.
• The physicians examined the relationship between birthweight and uric acid in this sample.
• They reported an inverse association between birthweight and uric acid after adjustment for sex, age, race, obesity, and dietary sodium intake.
• Each 1 kg increase in birthweight was associated with decreased uric acid by 0.11 mg/dL (95% CI: –0.16 to –0.06; model R²= 0.32).
• This relationship was stronger in adolescents with elevated blood pressure (β = –0.25; 95% CI: –0.44 to –0.06; R²= 0.50) but persisted in adolescents with normal blood pressure (β = –0.10; 95% CI: –0.15 to –0.05; R² = 0.31).