Tasevska N, et al. - Researchers assessed the link between total sugars (TS) consumption and type 2 diabetes (T2D) and cardiovascular disease (CVD) risk in 82,254 postmenopausal women of the Women's Health Initiative-Observational Study, with a follow-up of 16 years. They used regression calibration equations developed based on the predictive biomarker for TS and recovery biomarker for energy. They assessed these links before and after dietary calibration. From energy substitution (ES) and energy partition (EP) models, the estimated multivariable hazard ratios (HRs) for total CVD were 0.97 and 0.91, respectively. Overall, in both multivariable ES and EP models, a significant inverse association, generated by uncalibrated TS, with T2D and total CVD risk was demonstrated.