Duvauchelle T, et al. - This study involved the evaluation of the adequacy of Anapen via a comparison of the depot localization, plasma pharmacokinetics, and cardiovascular responses of adrenaline delivered via Anapen vs a prefilled syringe with a 25.4-mm needle. Findings revealed that with respect to autoinjector efficacy, needle length and intramuscular injection were not absolute requirements, but as the assessment of their therapeutic relevance in anaphylaxis is concerned, monitoring of injection location, biphasic adrenaline levels, and cardiovascular responses is crucial.