Zeinomar N, et al. - Using data from the Prospective Family Study Cohort (ProF-SC), researchers estimated the hazard ratios(HRs) and 95% confidence intervals(CIs) to assess the relationship of benign breast disease(BBD) with breast cancer(BC) risk and to ascertain the impact of underlying familial risk profile(FRP) on this relationship. They included 4,704 females with a history of BBD diagnosis. They also noted an association of BBD with a greater risk of BC (HR=1.31) and was not impacted by underlying FRP, with HRs of 1.35, 1.26, and 1.40, for categories of full lifetime BOADICEA score <20%, 20% - <35%, ≥ 35%, respectively. They did not find any link with BRCA1 mutations, women with BRCA2 mutations or for women without a known BRCA1 or BRCA2 mutation.