Cohen-Cymberknoh M, Reiss BG, Reiter J, et al. - In this multicenter-retrospective cohort study, researchers sought to examine the correlation of baseline disease severity, pancreatic insufficiency (PI), and Pseudomonas aeruginosa (PA) infection with fertility, the pregnancy course, delivery, neonatal outcome, and subsequent disease progression. Data were obtained from ten CF centers worldwide on patients who had been pregnant during 1986-2018. According to forced expiratory volume % predicted in 1 second (FEV ₁) and BMI, disease severity [mild or moderate-severe (mod-sev)] was defined. Data were available for 171 pregnancies in 128 patients 18-45 years of age; 55.1% for mod-sev disease, 43.1% for PI, and 40.3% with PA. Baseline disease severity, PA infection, and PI have an adverse effect on infant outcomes but do not substantially affect the progression of the disease during and after pregnancy. Therefore, pregnancies may have a good prognosis in severe CF patients.