Solanky D, et al. - Using a large, prospective cohort of patients in which all esophageal biopsies undergo expert gastrointestinal pathologist review, researchers analyzed factors predictive of progression from nondysplastic Barrett esophagus (NDBE) or low-grade dysplasia (LGD) to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). A prospective registry in a tertiary care center identified NDBE and LGD subjects. A total of 318 were involved with NDBE and 301 with Barrett esophagus (BE)-LGD. Findings revealed that BE length, presence of LGD, and nodularity were independent predictors of progression to HGD/EAC in this well-defined cohort of NDBE and BE-LGD subjects. These factors can help identify subjects at high risk who may benefit from closer endoscopic surveillance/therapy.