Kotecha D, et al. - In a real-world population, researchers extended the importance of B-type natriuretic peptide (BNP) to include adverse cardiovascular events and death in patients with suspected coronary artery disease, even at a low elevation of BNP (suggestive of subtle cardiac impairment). They evaluated 522 patients with 21% prior revascularization. In risk-modified patients assessed for coronary disease, conventional risk factors and other markers of arterial compliance, inflammation, and autonomic function had limited value for prediction of long-term outcomes. BNP had a strong connection with death and cardiovascular events, even without heart failure or overt ventricular dysfunction, and independent of revascularization. The investigators suggested that BNP > 100 pg/mL may be able identify patients with subtle cardiac function impairment that might benefit from early, targeted, and individualized management to improve prognosis.